Laboratory evaluation of Resveratrol antioxidant and anti-inflammatory effect on vascular function

Abstract

Introduction: Resveratrol is a natural phytoalexin whose main benefits are due to its anti-inflammatory and antioxidant properties. Its effects suggest that this is a useful supplement for reducing inflammation and may play a key role in cardiovascular disease prevention. It promotes vasodilation by induction of nitric oxide (NO) synthesis, has antithrombotic activity and prevents platelet aggregation. Vascular endothelial growth factor (VEGF) is responsible for angiogenesis, and
its expression is influenced by resveratrol. Objectives: To evaluate the effect of resveratrol on the vascular profile by determining blood pressure and interleukin-6 (IL-6), C-reactive protein (CRP), VEGF and NO biomarkers. Material and Methods: 27 students aged 18-22 were divided into control group (CG) and intervention group (GI), who consumed placebo and resveratrol 100 mg per day, respectively, for 1 month. Blood pressure was measured with a validated automatic device. CRP levels were obtained by immunoturbidimetry, IL-6 and VEGF by slot blot and NO quantification by
spectrophotometry. Results: There was a decrease in brachial and central blood pressure between the groups (??0.05). The negative variation in NO was higher in the CG although the differences were not significant (p>0.05). In the remaining markers evaluated no significant differences were observed. Conclusions: Regular intake of resveratrol seems to be a
preventive approach at the vascular level, as it positively modulates the vascular profile, reducing blood pressure. Variation in NO levels may help explain the benefits.