Biomateriais sintéticos e xenógenos com alto potencial clínico para reparo tecidual

Abstract

The main aim of the present study was to perform a literature review on the use of xenogenic and synthetic bomaterials for tissue healing. Regarding ceramic materials, hybrid hydroxyapatite and ?-TCP (60-70/40-30 wt%), apatite carbonate, demineralized bovine bone mineral (DBBM) are ordinary bone graft materials. However, the absorption rate
and biologic response of synthetics is slower than those for xenogenic graft materials. Regarding several polymers,
xenogenic materials (e.g. collagen, chitosan) have shown a biologic response proper for tissue healing when compared to synthetic polymers (e.g. PLGA, PLDLA). Thus, the bone healing involves cell migration, protein and mineral adsorption, angiogenesis, and the tissue formation. The development of synthetic polymers with a bio-absorption rate in synergism with the tissue healing and angiogenesis has been the focus of recent studies. Therefore, the combination of synthetic and xenogeneic graft materials become a strategy for enhanced tissue healing.